Bringing the vasopressin story into the realm of disease risk prediction, Prof Olle Melander (Sweden), concluded the session. Prof Melander sought to answer the question: Is excess vasopressin the “factor X” in cardiometabolic syndrome, type 2 diabetes and cardiovascular disease? Presenting a combination of animal and human studies, Prof Melander identified data suggesting that elevated levels of -copeptine can predict the development of a phenotype resembling a mild form of Cushing’s Syndrome and that elevated levels of copeptin links to increased abdominal obesity, insulin resistance, hypertension and reduced kidney function. In conclusion, Prof Melander suggested reduction of vasopressin through increased water intake could be a promising candidate for prevention of cardiometabolic disease.
H4H Young Researcher Award Winner
A highlight of the Evian conference each year is the awarding of the H4H Young Researcher Award. Prof Evan Johnson from the University of Wyoming won for his research on water intake and insulin resistance in type 2 diabetes. We will likely hear more from Prof Johnson in coming years!
Preventing Kidney Disease
Returning for the afternoon sessions, kidney health was on the agenda as we heard more about the new initiative conducted in conjunction with the International Society of Nephrology (ISN), Hydration for Kidney Health. Prof Louise Moist (Canada), offered details of the program, designed to expand the scientific evidence, integrate awareness and create sustainable momentum in hydration for kidney health research. To kick off the initiative, Prof Moist announced a new investigators grant.
Detailing the gravity of acute kidney injury, Prof Guisseppe Remuzzi, past President of the ISN, offered an update on ISN’s human rights initiative ,“0by25,” looking to prevent all deaths by acute kidney injury by 2025. The goals of the 0by25 initiative include:
- To address the current lack of data on the global burden of AKI, especially in low and middle-income countries.
- To raise awareness of AKI across the global healthcare community including among healthcare professionals, patients and, more widely, among governments and public health institutions and the private sector.
- To contribute to developing a sustainable infrastructure by implementing “need driven” approaches in selected areas for education and training and care delivery.
Documenting the progress made through the initiative, Prof John Feehally (UK) and former ISN President detailed more on the 0by25 initiative by reviewing the results of the “Global Snapshot on AKI”. A web-based prospective data collection survey carried out in more than 400 patients in at least 80 countries over the course of 8 weeks, the Global Snapshot looks at symptoms, lab results and enrollment in the program.
Initial results included:
- Dehydration is among the top three causes of AKI, induced from vomiting, diarrhea or lack of access to a safe water source.
- Dehydration is the second most important contributory factor for AKI.